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pentobarbital will lessen the extent or influence of almotriptan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.pentobarbital will decrease the level or effect of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with potent CYP3A4 inducers is not proposedpentobarbit